Effect of jinfu kang to experimental precancerous colon lesions and urinary metabolites in rat / 中国中药杂志
Yin-ping QIU; Ming-ming SU; Da-zheng WU; Ai-hua ZHAO; Yu-min LIU; Wei JIA.
China Journal of Chinese Materia Medica
; (24): 2653-2657, 2008.
Artículo
en Zh
| WPRIM | ID: wpr-324831
<p><b>OBJECTIVE</b> To profile urinary metabolite variations from 1, 2-dimethylhydrazine (DMH)-induced precancerous colon rats, Jinfu Kang treated rats and healthy controls.</p><p><b>METHOD</b>We used ethyl chloroformate derivatization and gas chromatography-mass spectrometry (GC-MS) based metabonomic method to analyze rat urines.</p><p><b>RESULT</b>The time-dependent variations of metabolite profile showed a progressive deviation of the metabolism in the model group from the initial pattern over time and a systemic recovery of the metabolism in the treatment group, which is consistent with the histological results. The in-depth analysis indicated that the disorder of tricarboxylic acid cycle (TCA), tryptophan metabolism, polyamine metabolism and gut flora structure were associated with DMH intervention.</p><p><b>CONCLUSION</b>Metabolic study revealed that Jinfu Kang can effectively reverse metabolic departures in DMH-induced precancerous colon rat, which is consistent with pathological results.</p>
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