<p><b>OBJECTIVE</b>To compare the
efficacy between micro invasive occlusion
procedure and
extracorporeal circulation procedure for treating
patients with simple
ventricular septal defect.</p><p><b>
METHODS</b>Two hundred and twenty
patients with simple
ventricular septal defect (except subarterial
ventricular septal defect) were randomly divided into micro invasive group (n = 116) and traditional
cardiopulmonary bypass surgery group (n = 104). Clinical data were collected and compared at baseline and at 3, 30 and 180 days after
surgery.</p><p><b>RESULTS</b>Age,
gender,
body weight and
ventricular septal defect type were
similar between the two groups (all P > 0.05). Operation
time and
hospitalization duration were significantly shorter in the micro invasive group than the traditional
cardiopulmonary bypass surgery group (all P < 0.05). The proportion of
blood transfusion was less in micro invasive group than the traditional
cardiopulmonary bypass surgery group [2.59% (3/116) vs. 72.12% (75/104), P < 0.01]. Three days after
surgery,
incidence of mild and above tricuspid insufficiency was less in micro invasive group than the traditional
cardiopulmonary bypass surgery group [0.86% (1/116) vs. 2.88% (3/104), P < 0.05]. There was one
patient developed mild
pericardial effusion at 30 days post
surgery in micro invasive group. There was no intracardiac
infection in the two groups during follow-up. At 30 and 180 days post
surgery,
incidence of residual shunt was also less in micro invasive group than the traditional
cardiopulmonary bypass surgery group [1.72% (2/116) vs. 7.69 (8/104) and 0(0/116) vs. 7.69(8/104), all P < 0.05]. After
surgery for 3, 30 and 180 days,
transthoracic echocardiography derived chamber size, left
ventricular end-diastolic volume index and left
ventricular ejection fraction were
similar between the two groups (all P > 0.05).</p><p><b>CONCLUSIONS</b>The
efficacy is
similar for
patients with simple
ventricular septal defect (except subarterial
ventricular septal defect) using micro invasive occlusion
therapy or
extracorporeal circulation surgery. Micro invasive occlusion
procedure can shorten operation and
hospitalization time, and reduce the need for
blood transfusion and
risk of developing procedural-related tricuspid insufficiency and post-procedural residual shunt.</p>