<p><b>OBJECTIVE</b>To observe the
clinical efficacy of comprehensive
treatment of
Chinese medicine in treating
ulcerative colitis (UC) according to
syndrome differentiation
therapy and the stage of
disease .</p><p><b>
METHODS </b>Fifty-three
patients with mild or moderate, initial onset or relapsed active UC of large intestinal dampness-
heat syndrome were randomly assigned to two groups, the
treatment group (27 cases) and the
control group (26 cases). The
treatment group was treated with oral Qingchang Huashi Recipe (QHR) and external application of Guanchang Recipe (GR) in the active
stage, oral administration of Fuzheng Qingchang Recipe in the remission stage. Symptomatic modification was performed according to the features of the symptoms.
Patients in the
control group were treated with oral
Mesalazine enteric coated
tablet (MSRT, 1.0 g, 4 times daily) in the active
stage, oral administration of MSRT (0.5 g, three times daily) in the remission stage. The main clinical symptoms,
Chinese medicine syndrome , induced remission rate, and changes of
quality of life were observed on the 28th, 56th, and 84th day
after treatment .</p><p><b>RESULTS</b>After 84 days of
treatment , the scores of the symptoms such as
diarrhea , passing stool with
pus and
blood , and the
abdominal pain in the
treatment group were obviously improved when compared with before
treatment (P < 0.05). The scores of the symptoms such as
diarrhea , and passing stool with
pus and
blood in the
treatment group were better than those in the
control group (P < 0.05). After 28, 56, and 84 days of
treatment , the
clinical efficacy of
Chinese syndromes were 77.78%, 77.78%, and 88. 89%, respectively, and the induced remission rates were 63.0%, 77.8%, and 88.9%, respectively in the
treatment group, better than those in the
control group of the same phase (P < 0.05). After 84 days of
treatment , the scores of the
quality of life , the
general symptoms , the emotional capacity, and the social capacity, tc. in the
treatment group and the
control group were improved than before
treatment (P < 0.05). Besides, the scores of the
quality of life in the
treatment group were superior to that in the
control group (P < 0.05).</p><p><b>CONCLUSIONS</b>Comprehensive
treatment of
Chinese medicine in treating
ulcerative colitis based on two steps according to the stage of
disease can effectively improve the main symptoms of UC
patients , improve the
Chinese syndromes , elevate the clinical remission rate and
patients '
quality of life . It showed favorable
clinical efficacy .</p>