<p><b>OBJECTIVE</b>To study the
toll-like receptor 2 (TLR2) Arg753Gln
gene polymorphisms of
acne patients of Gan-
depression induced
qi stagnation
syndrome and damp-
heat in the interior
syndrome , thus laying the
foundation for
genetics studies on its occurrence.</p><p><b>
METHODS </b>The distribution and the frequency of allelic
genes were studied in 75
acne patients of damp-
heat in the interior
syndrome , and 87
acne patients with Gan-
depression induced
qi stagnation
syndrome , as well as 70
healthy subjects (as the normal
control group ) using
polymerase chain reaction -
restriction fragment length polymorphism (
PCR -
RFLP )
technique .</p><p><b>RESULTS</b>There was significant difference in the frequency of the
genotype Arg/Gln + Gln/Gln in the TLR2 Arg753Gln
genetic polymorphisms [26. 44% (23/87) in Gan-
depression induced
qi stagnation
syndrome , 41.33% (31/75) in damp-
heat in the interior
syndrome , and 12.86% (9/70) in the normal
control group ] (P < 0.05).</p><p><b>CONCLUSION</b>The existence of 753Gln
allele in the Arg753Gln of TLR2 increased the onset
risk of
acne patients of Gan-
depression induced
qi stagnation
syndrome and damp-
heat in the interior
syndrome .</p>