<p><b>OBJECTIVE</b>To evaluate whether
glycation of
high-density lipoprotein (HDL) increases
cardiovascular risk in
patients with
type 2 diabetes mellitus by altering its anti-atherogenic property.</p><p><b>
DATA SOURCES</b>Data cited in this
review were obtained mainly from
Pubmed and
Medline in English from 2000 to 2013, with
keywords "
glycation", "HDL", and "
atherosclerosis". Study selection Articles regarding
glycation of HDL and its
role in
atherogenesis in both
humans and
experimental animal models were identified, retrieved and reviewed.</p><p><b>RESULTS</b>
Glycation alters the structure of HDL and its associated
enzymes, resulting in an impairment of atheroprotective functionality and increased
risks for cardiovascular events in type 2 diabetic
patients.</p><p><b>CONCLUSION</b>
Glycation of HDL exerts a deleterious effect on the development of cardiovascular
complications in diabetes.</p>