Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province / 生物医学与环境科学（英文）
Ming-Yan XU; Kun-Xue HONG; Xiao-Ling DENG; Jun LI; Hong PENG; Yu-Hua RUAN; Guan-Ming QIN; Hui XING; Xiao-Hu XU; Yi-Ming SHAO.
Biomedical and Environmental Sciences
; (12): 203-208, 2004.
Artículo
en Inglés
| WPRIM | ID: wpr-329641
<p><b>OBJECTIVE</b>To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection.</p><p><b>METHODS</b>One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP.</p><p><b>RESULTS</b>The frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects.</p><p><b>CONCLUSION</b>HLA-B*46 may be associated with its susceptibility to HIV-1 infections.</p>
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