Data from the first PBSC collections of 155 healthy donors between 2007 and 2010 were analyzed. Side effects were assessed using adverse eventinventory, which was graded from 1 (mild) to 3 (severe) or 4 (disabling).
RESULTS:
G-CSFadministration caused an elevation of WBC counts (mean 44,834/microL) and 86% of them were neutrophils. The mean mononuclear cells in apheresis products was 6.6x10(8)/kg and mean CD34+ cells was 6.0x10(6)/kg. Bonepain was reported by 151 healthy donors (97%) and severe bonepain was related to more CD34+ cells in apheresis products (P=0.041) 39 for grade 1 (5.1x10(6) CD34+cells/kg), 86 for grade 2 (6.0x10(6)), and 26 for grade 3 (7.1x10(6)). In addition, the percentage of collecting more than 5.0x10(6) CD34+cells/kg during the first leukapheresis showed correlation with the severity of bonepain.
CONCLUSION:
Bonepain was the most common side effect of G-CSF mobilization and more CD34+ cells were harvested in cases of severe bonepain.