<p><b>OBJECTIVE</b>To investigate
apoptosis of
tumor infiltrating
dendritic cells (TIDC) and their expression of Fas/FasL (CD95/
CD95L) in
human endometrioid adenocarcinoma.</p><p><b>
METHODS</b>The apoptotic rate of TIDC was measured in 45 cases of
endometrioid adenocarcinoma and 20 cases of normal
endometrium tissues (control) by double-label
immunohistochemistry using the
monoclonal antibody S-100 protein and
TUNEL technique. The expressions of Fas and FasL in TIDCs were detected using double-label
immunohistochemistry and imaging
analysis.</p><p><b>RESULTS</b>The apoptotic rate of TIDCs in
endometrioid adenocarcinoma were significantly higher than that in normal endormetrium [(13.02∓0.64)% vs (6.82∓0.53)%, P<0.05]. The expression levels of Fas in the TIDCs were significantly lower, whereas FasL expression significantly higher in
endometrioid adenocarcinoma than in normal endormetrium (7.88∓1.05 vs 19.25∓3.03, P<0.05; 12.95∓2.25 vs 7.51∓1.14, P<0.05).</p><p><b>CONCLUSION</b>Increased
apoptosis of the TIDCs and abnormal expression of Fas/FasL in TIDCs in
endometrioid adenocarcinoma may
lead to
tumor immune escape.</p>