Aging is a gradual process during the loss of functions in
cells,organs and
tissues by
time. The molecular mechanisms of
aging-related theories include the classical ones such as
telomere,
oxygen radical and nonenzymatic
glycosylation,as well as the newly proposed ones such as
DNA methylation,
mitochondrial DNA (
mtDNA)and
autophagy. The latest study showed the anti-
aging effect of
autophagy in
hematopoietic stem cells. In recent years,based on the molecular regulative mechanisms of
aging,a number of the promising anti-
aging drugs have been found,including
nicotinamide mononucleotide(NMN)and FOXO4-DRI,a
peptide of anti-
aging. In addition,there are many new discoveries in the field of
plant extracts,in which,the extracts from
Chinese herbal medicine(CHM),some single CHMs and the classical
prescriptions of CHM,represented by
curcumin and
resveratrol,have the partial anti-
aging effects by regulating the molecular mechanisms of
aging both in vivo and
in vitro. In brief,developing or exploring anti-
aging drugs,especially the natural
drugs,is one of the main development directions in the field of
anti-aging research in the basis of the molecular regulative mechanisms of
aging.