Severe Osteomyelitis as a Complication of Tokyo-172 BCG Vaccination
Hyo-Jin KWON; Bo-Hyun CHUNG; Byung-Min CHOI; Kyung-Un PARK; Yun-Kyung KIM.
Journal of Korean Medical Science
; : 221-224, 2012.
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| WPRIM | ID: wpr-33790
The bacilli Calmette-Guerin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive for BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.
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