A new sesquiterpene from Chinese agarwood induced by artificial holing / 中国中药杂志
Tong-Dong KUANG; Hui-Qin CHEN; Wei LI; Jin-Ling YANG; Li-Man ZHOU; Cai-Hong CAI; Wen-Hua DONG; Wen-Li MEI; Hao-Fu DAI.
China Journal of Chinese Materia Medica
; (24): 4618-4623, 2017.
Artículo
en Zh
| WPRIM | ID: wpr-338228
In order to study the chemical constituents of n-butanol fraction of ethanol extract from Chinese agarwood induced by artificial holing, various chromatographic techniques were carried out to isolate compounds, and the structures of compounds were determined through a combined analysis of physicochemical properties and spectroscopic evidence. Seven compounds were obtained and identified as selina-3,11-dien-9,15-diol (1), aquilarone D (2), 5α,6β,7α,8β-tetrahydroxy-2-[2-(2-hydroxyphenyl)ethyl]-5,6,7,8-tetrahydrochromone (3), 6,7-dimethoxy-2-[2-(4-methoxyphenyl)ethyl]chromone (4), syringin (5), methyl (Z)-p-coumarate (6), and 4'-methoxycinnamic acid (7), among which compound 1 was a new compound and compounds 5-7 were isolated from agarwood for the first time. The bioactivity assay results concluded that compounds 6 and 7 showed certain nematicidal activity against Panagrellus redivivus, and compounds 4, 6 and 7 exhibited cytotoxicity against BEL-7402, SGC-7901 and A549 carcinoma cell lines.
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