Down-regulated expression of NPM1 in IMS-M2 cell line by (-)-epigallocatechin-3-gallate
Hoang-Thanh CHI; Bui-Thi-Kim LY; Hoang-Anh VU; Yuko SATO; Phu-Chi DUNG; Phan-Thi XINH.
Asian Pacific Journal of Tropical Biomedicine
; (12): 570-574, 2014.
Artículo
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| WPRIM | ID: wpr-343196
<p><b>OBJECTIVE</b>To investigate the inhibited effect of epigallocatechin-3-gallate (EGCG) on the expression of NPM1 in IMS-M2 cells harboring the NPM1 mutations.</p><p><b>METHODS</b>Cell proliferation assay was performed to test the effects of EGCG on cell growth of IMS-M2 cells harboring the NPM1 mutations. Western blot analysis were performed to test the protein expression of NPM1, AKT, those associated with apoptosis.</p><p><b>RESULTS</b>EGCG can down-regulate the expression of NPM1 in IMS-M2 cells harboring the NPM1 mutations. Moreover, EGCG also suppressed the cell proliferation and induced apoptosis in IMS-M2 cells.</p><p><b>CONCLUSIONS</b>The results suggested that EGCG could be considered as a reagent for treatment of AML patients with NPM1 mutations.</p>
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