<p><b>OBJECTIVE</b>To study the effects of cardiovascular function in dental extraction on hypertensive patients by inhalation 50% nitrous oxide.</p><p><b>METHODS</b>The 30 hypertensive patients were randomly allocated into two groups A group inhalation the 50% nitrous oxide and oxygen, B group inhalation the air and O(2). To measured the HR, BP, and SpO(2) in dental extraction.</p><p><b>RESULTS</b>In a group the changes of blood pressure and heart rate are more smoother than B group. Two groups were significant in HR, BP and SpO(2) (P < 0.01).</p><p><b>CONCLUSIONS</b>Inhalation with 50% nitrous oxide can keep the stability of cardiovascular system and it is a valid method in dental extraction on hypertensive patients.</p>