<p><b>OBJECTIVE</b>To study the correlation between
vitamin D receptor genetic polymorphism Fokand
vitamin D deficiency rickets in
children between 1 to 3 years old, and to explore the significance of hereditary factors in the development of
vitamin D deficiency rickets.</p><p><b>
METHODS</b>Sixty-two
children with
vitamin D deficiency rickets and 60 healthy
children as a
control group were enrolled.
Serum levels of
25-hydroxyvitamin D3 were measured using
ELISA.
Polymerase chain reaction-
restriction fragment length polymorphism (
PCR-
RFLP) genetic
analysis method was used. A
restriction fragment length polymorphism in the
vitamin D receptor genetic polymorphism Fok I was tested. The frequencies of the
vitamin D receptor genotype and
allele were compared between the two groups.</p><p><b>RESULTS</b>
Serum 25-hydroxyvitamin D3 levels in the
rickets group were significantly lower than those in the
control group ( 9.1+/-4.1 ng/mL vs 16.1+/-6.9 ng/mL; P<0.05 ). FF
genotype in the
vitamin D receptor genetic polymorphism Fok I was more common in the
rickets group than in the
control group (53% vs 25%; P<0.05). F
allele frequency in the
rickets group was significantly higher than that in the
control group (73% vs 57%; P<0.05).</p><p><b>CONCLUSIONS</b>There is a correlation between
vitamin D receptor genetic polymorphism Fok I and
vitamin D deficiency rickets. This suggests that
vitamin D receptor genetic polymorphism might
play an important
role in determining susceptibility to development of
vitamin D deficiency rickets.</p>