The protective effects of SB203580 against mortality and radiation induced intestinal injury of mice / 药学学报
Jian-hui CHANG; Heng ZHANG; Fang-xia GUAN; Yue-ying WANG; De-guan LI; Hong-ying WU; Cheng-chun WANG; Chang-hui ZHOU; Zhi-bin ZHAI; Lu LU; Xiao-chun WANG; Qi HOU; Ai-min MENG.
Acta Pharmaceutica Sinica
; (12): 395-399, 2011.
Artículo
en Zh
| WPRIM | ID: wpr-348942
This study is to investigate the protective effects of the SB203580 against radiation induced mortality and intestinal injury of mice. A total of 67 male C57BL/6 mice (20.0-22.0 g) were matched according to body weight and randomly assigned to one of three groups control, total body irradiation exposure (IR, 7.2 Gy) only, and IR (7.2 Gy) + SB203580 (15 mg x kg(-1)). 30 days survival rate was observed in the experiment. In intestinal injury experiment, the expression levels of caspase-3, Ki67, p53 and p-p38 were assayed in the mice intestine crypts. The results showed that the 30 days survival rate was 100% (control), 0 (IR) and 40% (IR+ SB203580), separately. Compared to the IR groups, the positive cells of caspase-3, p53 and p-p38 in crypt cells decreased 33.00%, 21.78% and 34.63%, respectively. The rate of positive cells of Ki67 increased 37.96%. Significant difference was found between all of them (P < 0.01). SB203580 potently protected against radiation-induced lethal and intestinal injury in mice, and it may be a potential radio protector.
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