Preliminary observation on the efficiency and safety of Lamivudine used in decompensative hepatic cirrhosis (B) accompanied by hypersplenism / 浙江大学学报·医学版
Nian-Feng ZHAO; Guan-Guan SU; Yong ZHOU.
Journal of Zhejiang University. Medical sciences
; (6): 461-463, 2002.
Artículo
en Zh
| WPRIM | ID: wpr-349419
OBJECTIVE:
To study the efficacy and safety in patients with decompensative hepatic cirrhosis treated with Lamivudine.METHODS:
Eighteen decompensative hepatic cirrhosis (B) (active phage) patients accompanied with hypeersplenism were treated with Lamivudine 100mg po. per day. The total course of treatment was 3 months to 6 months when HBVDNA became negative and HBeAg seroconversion occurred in these patients after Lamivudine treatment. The efficacy and safety in patients were evaluated as follows HBVDNA were negative, HBeAg seroconversion occurred and hepatic cirrhosis child-stageing changed. The efficacy and safety between treated group and contrast group were compared during treatment with Lamifudine for 1 year and follow-up foe 1 year after completing treatment.RESULTS:
The total efficacy of treated group was 27.7% and 71.43% respectively during the phase II trial and the safety was good in these patients.CONCLUSION:
The efficacy and safety of Lamivudine are good while it is used in non-registered adaptation of decompensative hepatic cirrhosis with hypersplenism.
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