Pilot study of a cell membrane like biomimetic drug-eluting coronary stent / 生物医学工程学杂志
Dezeng FAN; Zhiyuan JIA; Xinhao YAN; Xiaolei LIU; Wei DONG; Fuyu SUN; Jian JI; Jianping XU; Kefeng REN; Weidong CHEN; Jiacong SHEN; Hong QIU; Runlin GAO.
Journal of Biomedical Engineering
; (6): 599-602, 2007.
Artículo
en Zh
| WPRIM | ID: wpr-357643
A novel bioinspired phospholipid copolymer has been synthesized by the radical polymerization of poly2-Methacryloyloxyethylphosphorylcholine (MPC), stearyl methacrylate (SMA), hydroxypropyl methacrylate (HPMA) and trimethoxysilylpropyl methacrylate (TSMA). Contact angle results indicated that the coating surface rearranged to get a more hydrophilic surface at the polymer/water interface. The membrane mimic phosphorylcholine coating surface could resist the platelet adhesion and prolong plasma recalcification time significantly. Rapamycin was used as model drugs to prepare drug-eluting coating. The animal experiments showed that this novel drug-eluting stent could effectively prevent the phenomena of restenosis.
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WPRO
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