B lymphocyte counts and Toil-like receptor 9 mRNA expression on cell from HIV-1 infected patients / 中华微生物学和免疫学杂志
Hong SUN; Wenqing GENG; Hualu CUI; Min ZHAO; Xiaoxu HAN; Zining ZHANG; Jing LIU; Di DAI; Yanan WANG; Yongjun JIANG; Hong SHANG.
Chinese Journal of Microbiology and Immunology
; (12): 860-863, 2010.
Artículo
en Zh
| WPRIM | ID: wpr-383301
Objective To study the B lymphocytes counts and the expression of TLR9 mRNA on B lymphocytes in peripheral blood from Chinese HIV-infected patients.Methods The cells from peripheral blood were stained with antibodies labeled with fluorescence and B lymphocytes were counted with flow cytometry.Using the method of magnetic activated cell sorting and real-time PCR,the expression of TLR9 mRNA was measured.Results The B lymphocytes counts in HIV/AIDS patients was significantly lower than that of healthy controls(P ＜0.01).The B lymphocytes counts in HIV/AIDS patients positively correlated with the CD4 +T cells counts(r =0.534,P = 0.006).The expression of TLR9 mRNA on B lymphocytes in HIV/AIDS patients was significantly lower than that of healthy controls(P =0.023),and positively correlated with the CD4 + T cells counts(r = 0.390,P = 0.040).Conclusion The B lymphocytes counts and the expression of TLR9 mRNA on B lymphocytes in Chinese HIV/AIDS patients were decreased due to HIV infection,which may correlate with disease progression.
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