Stem ceils
transplantation is one of the potential
therapeutic strategies for
Alzheimer's disease (AD). Many
animal models following
stem cell transplantation showed improvement in
memory and
cognitive function. However, the pathological changes in AD, such as arnyloid beta deposits, negatively
affect the
survival and differentiaition of
stem cells.
Stem cells transfectcd with
neprilysin or
administration of phenserine could at-
tenuate these
adverse effects. Genetic modification of
stem cell by over expression of
neurotrophic factors could attenuate the
adverse effects not only on
stem cells but also on degenerative
neurons. Further investigation on how to overcome the
adverse effects of phathological factors in AD on
stem cells and maximize the
therapeutic effects of
stem cells would support the
hope for introduction of
stem cells transplation into clinical application.