Objective To study the pathogens and
drug resistance profiles of pulmonary
infection in
patients with
AIDS.
Methods The pathogens and their
drug susceptibility of pulmonary
infection diagnosed by fibrobronchescopy-induced brunchoalveolar
lavage fluid (BAI.F)
culture and/or transbronchial
biopsy in 116
AIDS cases were analyzed. Results Monopathogenic
infection in
lungs were detected in 18 cases(15.5%) and
mixed infection in 98 cases ( 84.5%). Of the 116 cases,
bacteria were present in 91
patients,
fungi in 62, tubercle
bacillus in 49,
pneumocystis jiroveci in 29, and
cytomegalovirus in 11.Ninety-five bacterial
strains were isolated from BALF, mainly including Streptococci (34),
coagulase negative
Staphylococcus (20),
Klebsiella pneumoniae (10) and
Escherichia (7). The isolated
bacteria were resistant to β-
lactam,
macrolides,
quinolones and
aminoglycosides, of which were 14
methicillin-resistant Streptococci (MRS)
strains and 12 extended spectrum β-lactamases (ESBL)
strains. Sixty-eight fungal
strains were isolated, including 36
Candida mycodermas, 19
Penicilliums, 6 Aspergilli and 5
Mold fungi;they were sensitive to
amphotericin B but resistant to fluconazol (5.6% -50. 0% ) and
itraconazole( 10. 5%-60. 0% ). Conclusion
Pneumonia in
AIDS patients are usually caused by multiple pathogens,predominantly consisting of multiresistant
bacteria and
fungi. Therefore,
antibiotics should be rationally chosen according to
drug susceptibility test.