Thirty seven
patients with
congestive heart failure (CHF) were divided into
cilazapril group (n=19) and general
treatment group (n=18).
Serum levels of
interleukin-6 (
IL-6) ,
interleukin-8 (
IL-8) ,
interleukin-10(
IL-10) and
tumor necrosis factor-α(TNF-α) , left
ventricular ejection fraction (LVEF) ,left ventricular end-diastolic diameter (LVEDD),
cardiac output (CO) and fractional shortening (FS) were measured before and
after treatment.
Serum levels of
cytokines were also measured in 40 healthy individuals (
control group).
Results:
The
serum levels of
IL-6,
IL-8,
IL-10 and TNF-α in CHF
patients were significantly higher than those in the
control group ( all P<0.01 ) ;
After treatment, the
serum IL-6,
IL-8 and TNF-α were significantly decreased (P<0.01 ,P<0.05 ) in the
cilazapril group. The LVEF, FS, CO were significantly increased in the
Cilazapril group ( P<0.01 ) ; And the
serum levels of
IL-6 were significantly decreased in the
cilazapril group as compared with the general
treatment group ( P<0.05 ), however,
after treatment, the EF, LVEF, FS and CO had no statistical differences in the
cilazapril group as compared with the general
treatment group. In the
control group only LVEF and FS improved(P<0.01) ;
Cytokine levels showed no changes. It suggests that
cilazapril can reduce the
serum levels of pro-inflammatory
cytokines, increased the
serum levels of anti-inflammatory
cytokine, protect and improved cardiac function in the
patients with
congestive heart failure.