Objective To evaluate the feasibility and
safety of vaginal enlarged
amputation of
cervix to treat
patients with
cervical cancer of stage Ⅰ a1 and
cervical intraepithelial neoplasia grade Ⅲ(CIN Ⅲ)
who were unfit for
conization surgery.
Methods From July 2002 to May 2007,
patients with
cervical cancer at stage Ⅰ a1,diagnosed by
pathology after loop electrosurgical excision
procedure(LEEP),large area CIN Ⅲ(the area of lesion≥3/4 on
colposcopy),CIN Ⅲ coexisted with vaginal intraepithelial
neoplasia (VAIN)in the superior segment of
vagina,CIN Ⅱ-Ⅲ
recurrence or with residual lesion,positive margin after
conization of
cervix,
who wanted to preserve
fertility and(or)corpus
uteri were selected to receive vaginal enlarged
amputation of
cervix.Results Forty-eight eases including 5 with
cervical cancer in stage Ⅰ a1,38 with large area CIN Ⅲ(9 with gland involvement),2 with residual lesion and 2 with positive margin after LEEP,1
recurrence after
cold knife
conization,received the
procedure successfully.The median age was 34 years(range 27-40),median operation
time was 60 minutes(range 30-100),median
blood loss was 40 ml(range 5-300),and median
hospital stay was 10 days(range 7-17).After follow-up 1-39 months,no
patient had
postoperative complications and
recurrence,and all
patients resumed normal
menstrual cycle and sexual
life.Condusion Vaginal enlarged
amputation of
cervix appears to be a safe and feasible
procedure for
patients with
cervical cancer at stage Ⅰ a1 and CIN Ⅲ
who are unfit for
conization surgery.