Abnormal
cell signal transduction is associated with the occurrence and development of
human diseases. Some
virus pathogenicity and
infection mechanism are due to
virus antigen protein acting on the host
cell signal transduction pathway, leading to host
cell signal transduction disorder.
Hepatitis C virus (HCV) is a major pathogen of
chronic hepatitis C, which causes
cirrhosis and
hepatocellular carcinoma. But the pathogenesis of HCV and
persistent infection mechanism remain far from clear. HCV pathogenesis may be related to the HCV
protein expression interfering host
cell signal transduction pathways. The studies of
hepatitis C virus proteins acting on host
cell signal transduction pathways, not only help to clarify the impact of its pathogenic mechanisms, but also benefit to new
drug design and development for new
treatment methods. This article summarizes the recent progress in
research on the effect of
hepatitis C virus protein in
cell signal transduction pathways in the past few years.