Compound aluminum sulfateinjection was i.m. injected into quadriceps of the rabbits. The in situ stimulation effect was observed macrographically. Blood samples were collected at different time after i.m. injection. Aluminum concentrations were determined by ICP-MS assay and simulated with DAS software. Tissuenecrosis as well as the healing of the bladder wall were observed macrographically or pathologically after the injection was given into dogbladder.
RESULTS:
Severe stimulation was observed after intra quadriceps injection, however, there was no obvious elevation of bloodaluminum concentration. The average AUC0-24 was 2.93±1.82 mg·h·L-1 (n=5), corresponding to a relative bioavailability of about 2.77%. Injecting in bladdermuscle necrotized the bladder wall in situ, but fibroblast generated and took place of the necrotized membrane and muscle four weeks after injection. There was no bleeding or perforation on the bladder wall.