Objective
Brain natriuretic peptide(BNP) is released from the
cardiac ventricles in response to increased wall tension. The prognostic significance of
blood brain natriuretic peptide in
Chinese patients with
cardiovascular disease has not been established. The purpose of this study was to investigate the value of
brain natriuretic peptide for predictin g
cardiac death within 1 month in
Chinese patients with
cardiovascular disease.
Methods One hundred and seven
inpatients with
cardiovascular disease, whose
blood brain natriuretic peptide concentration were measured within 1 - 3 days of admission, using
triage BNP test, were divided into 2 groups the
survival and the non-
survival, according to the results of 1was positively correlated with
heart rate, left ventricular end-diastolic dimension,
history of
heart failure and old
myocardial infarction (r=0.28, P=0. 000 4; r=0.49, P<0. 000 5; r=0.39, P<0. 000 5; r=Area under the curve of the receiver-operating-characteristic(ROC) of
brain natriuretic peptide to predict
cardiac death at 1 month in
patients with
cardiovascular disease was 0.89%, 95%
confidence interval 0.79-0. 98, P<0. 000 5; stepwise
logistic regression analysis indicated that
brain natriuretic peptide (≥755pg/mL) was the only independent predictor of
cardiac death at 1 month in
patients with
cardiovascular disease (OR= 17.6, 95 %
confidence interval, 8.7- 66.5, P<0. 000 5 ). Conclusion
Brain natriuretic peptide might predict
cardiac death at 1 month in
patients with
cardiovascular disease.