Objective To investigate the
diagnosis and
treatment of acute rejection of orthotopic
liver transplantation (OLT).
Methods From July 1999 to April 2000, two piggyback
liver transplantations were performed on two
patients with
Wilson's disease. Results
Cyclosporine A,
azathioprine and
methylprednisolone were the baseline
immunosuppression management. Acute rejection occured 5 times in the 2
patients. The correct
diagnosis was obtained through clinical inspection,
liver function test and
biopsy. The rejections were controlled by intensive steriod
therapy plus
OKT3 or
FK506. Conclusions Clinical inspection and
liver function test can suggest the episode of acute rejection in
time. Hepatic
biopsy is the key point for
diagnosis of acute rejecton, Reasonable use of immunosppression is critical for the
treatment.