Objective To investigate the relationship between
serum visfatin level and
coronary artery stenosis.
Methods Based on
coronary angiography,85
patients were diagnosed as
coronary heart disease.According to
oral glucose tolerance test,these
patients were divided into 3 groups,34
patients with normal
glucose tolerance(CHD group),25 with impaired
glucose regulation(CIG group),and 26 with
type 2 diabetes mellitus(CDM group).30 non-comary
heart disease subjects with normal
glucose tolerance were selected as the
control group(CON group),and they underwent coronary
CT angiography scan and were confirmed
coronary disease-free.
Blood pressure,
body mass index(BMI),
waist circumference(WC),
waist hip ratio(WHR),
fasting plasma glucose(FPG),
blood lipid analysis,
fasting insulin,and HbA1C were determined.
Serum visfatin concentration was assayed and the status of
coronary artery was assessed.
Coronary artery stenosis was screened by coronary interventional
angiography and assessed by Gemini scoring system in CHD,CIG,and CDM groups.Results Compared with
control group,
serum visfatin in CHD,CIG,and CDM groups were significantly higher(all P<0.05).Compared with CHD group,
serum visfatin in CIG and CDM groups were significantly higher(all P<0.05).The correlation
analysis showed that
serum visfatin level was positively correlated with the involved branches of
coronary arteries(r=0.807,P<0.01),
serum visfatin level was positively related with Gensini
coronary artery score(r=0.669,P<0.01).
Visfatin was also positively correlated with WC,WHR,
triglyceride(TG,r=0.200,P=0.032,r=0.185,P=0.047,r=0.321,P<0.01),while
high density lipoprotein cholesterol(HDL-C)was negatively correlated with
visfatin(r=-0.354,P<0.01).Multiple
regression analysis showed that senlm hvel of TG and WC were the main influencing factors of
visfatin.Conclusion (1)The level of
serum visfatin may reflect the severity of
coronary artery stenosis,
detection of
visfatin helps to make
early diagnosis of CHD.(2)The raised
serum level of
visfatin in comary
heart disease patients with imparied
glucose tolerance is consistent with clinical evidence that diabetic
patients have more severe
coronary diseases.(3)WC and
serum TG are main inilucencing factors,suggesting that
visfatin is correlated with
abdominal obesity.