ObjectiveTo investigate the influence of
Mycobacterium tuberculosis (MTB)
co-infection and other factors on the
HIV replication level in antiretroviral
treatment na(i)ve
patients.MethodsSix hundred TB
patients and 465
HIV infectors were recruited between April 2010 and September 2010.TB
coinfections were diagnosed in
HIV infected cases with
chest X-ray,checking TB in
sputum with anti-
acid staining and
culture of the
sputum,histopatholo
diagnosis and
clinical diagnosis.
HIV infections were screened in TB
patients with the 3rd generation
ELISA antibody test.Sixty-one antiretroviral
treatment na(i)ve
HIV/TB co-infectors and 34
HIV infectors with CD4
T cell count below 350
cells/μl were included in this study.Information about the
demography,
epidemiology and results of clinical
diagnostic tests of
HIV and TB was collected through pathography and
questionnaires from all participants.
HIV viral load were detected with COBAS AmpliPrep/COBAS TaqMan(R) System of Roche Company.ResultsThe
viral load of
HIV/TB co-infectors was (5.05±0.93) lg copies/ml,while the
viral load of
HIV infectors was (5.06±0.76) lg copies/ml,after control of age,
race,
marital status,
education,route of
HIV infection,
HIV clade and CD4
T cell count,there was no significant difference between the two groups (P=0.94).CRF01_AE
HIV-1 infection was associated with higher
HIV viral load compared with non CRF01_AE (OR=8.07,95% CI 1.07-61.20,P=0.04).ConclusionNo obvious effect of MTB
co-infection on
HIV replication level of
HIV infected cases with relatively low CD4
T cell count in Guangxi region,while the CRF01_AE
HIV infected individuals showed higher
viral load,we should raise concern on the
monitoring and
treatment on this
population.