Ninety six
female patients with
chronic renal failure were randomly allocated into combination group (n =48) and
control group (n =48).In combination group
patients received both
kidney transplantation and
hematopoietic stem cell infusion,in
control group patients underwent
kidney transplantation only.The results showed that chronic rejection in the combination group was lower than that in the
control group [2%(1/48)vs.17% (8/48),P<0.05)].The 1-,3-,5-and 10 y-
survival rates of
kidney in the combination group were 98% (47/48),94% (45/48),83% (34/41) and 9/17,respectively,those in
control group were 98% (47/48),90% (43/48),76% (31/41) and 7/17,respectively.Infusion of
donor hematopoietic stem cells can augment
chimerism in early
postoperative period and significantly reduce the rate of
graft rejection,which is beneficial for the
quality of life of the recipients.