Objective To explore the value of SOD activity in
diagnosis of
central nervous system leukemia (CNSL )by detec-
ting SOD activity of
cerebrospinal fluid of
patients with CNSL .
Methods The
cerebrospinal fluid of 55
patients from department of
hematology of Nanfang
hospital of southern medical
university were collected from January 2008 to January 2009 ,in which 30 pa-tients suffered with
central nervous system leukemia (CNSL group) ,the other 25
patients suffered with acute leucemia without im-paired
central nervous system(
control group) .The SOD activity of
cerebrospinal fluid was detected by the
xanthine oxidase meth-od ,while the routine test ,
biochemistry test and
cell smear of
cerebrospinal fluid was detected .Results There were
statistics differ-ence in the level of
white cell and
protein in
cerebrospinal fluid between CNSL and
control group (P0 .05) .There was
statistics difference in the level of SOD activity between CNSL and
control group(P<0 .05) .The
white cell quantity and the
protein level in
cerebrospinal fluid had negative corre-lation with the activity of SOD ,(r=0 .871 ,P=0 .000 ;r=0 .518 ,P=0 .003) .The activity of SOD in the
cerebrospinal fluid had sta-tistics difference before and after intrathecal
chemotherapy (P<0 .05) .The activity of SOD in the
cerebrospinal fluid whose under 45 year-old (755 .64 ± 345 .77) ,which was significant lower than that of the paitents whose equal with or above 45 year-old (1 420 .49 ± 307 .69)(P<0 .05) .Conclusion The changes of the SOD activity in the
cerebrospinal fluid had relation with
central nervous system leukemia ,and the SOD activity might be a auxiliary
diagnosis index used in
central nervous system leukemia by revi-sing
age factor .