Staphylococcus aureus and
Staphylococcus epidermidis strains isolated at eight large medical centers in
Korea were examined for
methicillin resistance and resistance to eight other
antibiotics;
cefazolin,
cefamandole,
cefuroxime,
cefoxitin,
cefotaxime,
moxalactam,
penicillin G and
vancomycin.
Methicillin resistance was found in 296 of 1225
strains (24.2%) of S. aureus and 126 of 348
strains (36.2%) of S. epidermidis. Methicillinresistant
strains were isolated from all sources with the frequency of isolation ranging from 11% to 60%. From
pleural effusion,
throat swab and
blood,
methicillin-resistant strains of S. aureus were more frequently isolated with statistical significance (Chi-squared test, 95% confidence). Almost all of
Methicillin-resistant S. aureus (
MRSA) and S. epidermidis (MRSE)
strains were multiply resistant to one or more tested eight
antibiotics. However only 7(2.4%) of 296
MRSA strains and 2(1.6%) of 126 MRSE
strains were resistant to
vancomycin.
Vancomycin was the most effective
antibiotic against staphylococcal isolates as well as
MRSA and MRSE.