A high-throughput
method for
screening drug multi residues was developed by quadrupole-
time-of-flight( Q-TOF)
mass spectrometry together with QuEChERS sample preparation
technique. It has been used for the
determination of 57
drugs, such as
tetracyclines ( TCs ) ,
sulfonamides ( SAs ) ,
quinolones ( QNs ) , triphenylmethanes (TPMs),
estrogens (ETs),
androgens (AGs) and
glucocorticoids (GCs) in fish. The optimized pretreatment conditions were examined. The target compounds were extracted with acetonitrile under the condition of Na2
EDTA-Mcllvaine
buffer, and the usage of clean-up
reagents was 25 mg anhydrous
magnesium sulfate, 12. 5 mg octadecylsilane and 6. 25 mg N-Propylethylenediamine sorbent for extracted
solvent of each milliliter. The positive results acquired by this high-throughput
method were confirmed by
liquid chromatography-
tandem mass spectrometry (
LC-MS/MS) . The
detection limit for these 59
drugs was in the range of 0. 5-5. 3 μg/kg. The
method is
time-saving, convenient, effective and wide coverage. Its
sensitivity can meet the requirement of the
detection of
drug residues in aquatic products.