Autoimmune neurological
diseases have a high
morbidity and
mortality,but are treatable if diagnosed earlier.Many auto-
antibodies may become important
laboratory biomarkers for the
diagnosis,evaluating severity,
prognosis,and even reflecting
treatment response,of these
diseases.With the development of new
knowledge and diagnostic
technology,there is a pending need for discovering new pathogenesis-based
biomarkers with high
sensitivity and specificity on
autoimmune diseases of the nervous system.To fulfill this
goal,the pathogenesis as well as translational studies in
autoimmune diseases of the nervous system are highly warranted.Multi-center randomized double-blinded clinical trials are also necessary to appropriately evaluate the clinical value of these auto-
antibodies.W henever possible,these validated
autoantibody assays are readily encouraged to perform and popularize these
methods in clinical practice.