CHINET 2012 surveillance of antibiotic resistance in Enterobacter spp .in China / 中国感染与化疗杂志
Zhongju CHEN; Ziyong SUN; Zhidong HU; Jin LI; Lianhua WEI; Ling WU; Yingchun XU; Xiaojiang ZHANG; Yuanhong XU; Jilu SHEN; Chuanqing WANG; Aimin WANG; Yuxing NI; Jingyong SUN; Zhaoxia ZHANG; Ping JI; Fu WANG; Demei ZHU; Fupin HU; Yunzhuo CHU; Chao ZHUO; Danhong SU; Yunsong YU; Jie LIN; Hong ZHANG; Jing KONG; Yunjian HU; Xiaoman AI; Bin SHAN; Yan DU.
Chinese Journal of Infection and Chemotherapy
; (6): 387-391, 2014.
Artículo
en Zh
| WPRIM | ID: wpr-456804
Objective To investigate the distribution and antibiotic resistance of clinical Enterobacter isolates .Methods A total of 3 031 clinical strains of Enterobacter were collected from 15 hospitals from January 1 through December 31 , 2012 . Antimicrobial susceptibility testing was performed with Kirby-Bauer or minimum inhibitory concentration method .The results were analyzed according to CLSI 2012 breakpoints .Results Enterobacter cloacae and Enterobacter aerogenes accounted for 73 .0% (2 212/3 031) and 23 .9% (725/3 031) of all the Enterobacter strains .The isolates of other Enterobacter species accounted for 3 .1% (94/3 031 ) . The main source of the isolates was respiratory tract specimen , accounting for 53 .2% (1 612/3 031) .Most (> 89% ) of the Enterobacter strains were resistant to cefazolin and cefoxitin . Generally ,54 .4% ,47 .5% and 34 .3% of the strains were resistant to cefuroxime ,cefotaxime and cefazidime ,respectively . About 6 .6% to 26 .3% of the strains were resistant to amikacin ,gentamicin ,piperacillin-tazobactam ,cefepime ,cefoperazone-sulbactam ,ciprofloxacin and trimethoprim-sulfamethoxazole .Imipenem ,meropenem and ertapenem showed the highest activity , to which only 3 .5% ,3 .7% and 10 .3% of the strains were resistant ,respectively .About 8 .9% (269/3 031) of the strains were resistant to at least imipenem ,meropenem or ertapenem .Four Enterobacter strains were extensive-drug resistant (XDR) .Conclusions The prevalence of antibiotic resistance in Enterobacter isolates decreased slightly in 2012 compared to the data in 2011 ,but the situation is still very serious .We should continue to take effective measures to control the resistant strains .
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WPRO
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