Objective To explore the clinical effect between
atorvastatin combined with
amlodipine and
amlodipine monotherapy for the
treatment of
hypertension .
Methods 116
patients with
primary hypertension were randomly selected.According to
treatment methods, they were divided into the
control group and the
observation group,60 cases in the
control group was given
amlodipine therapy.56
patients in the intervention group,with atorvasta-
tin treatment on the basis of the
control group.Systolic and diastolic
blood pressure before and after the
treatment,
carotid artery intima-media thickness (IMT) were observed,and carotid plaque area,
serum total
cholesterol (TC),
low density lipoprotein cholesterol ( LDL-C) and urinary
albumin ( mAlb) were detected.Results
After treatment, systolic
blood pressure of the
observation group and the
control group were (138.51 ±12.90) mmHg and (147.62 ± 13.45)mmHg,lower than those before
treatment(t=12.67,10.35,all P0.05).Conclusion There is a good clinical effect of
atorvastatin combined with
amlodipine for the
treatment of
hypertension and there is no obvious adverse reactions,which is worthy of clinical application.