Objective To investigate effect of
sorafenib on
serum hepatoma marker in
patients with advanced
hepatocellular carcinoma.
Methods 101
patients with advanced
hepatocellular carcinoma were selected, and divided into two groups.50 cases in
control group were treated with routine clinical
treatment, and 51 cases in experimental group were treated with
sorafenib on the basis of
control group.The
survival time, adverse reactions,
VEGF, CTGF, HIF-1 and OPN levels were compared after the
treatment.Results The
survival time of experimental group was higher than
control group (P<0.05).Compared with
control group, the
serum levels of
VEGF、CTGF,HIF-1, OPN,AFP, CEA, and CA199 in experiment group were lower (P<0.05,P <0.01).There were no significant differences of total adverse reactions between experimental group and
control group. Conclusion
Sorafenib can effectively prolong
survival time of
patients with advanced
hepatocellular carcinoma, reduce
serum VEGF, CTGF, HIF-1 alpha and OPN levels.