Objective To assess and compare the
roles of
plasma concentrations of
neutrophil gelatinase associated lipocalin (NGAL) and
Cystatin C for
early diagnosis and
treatment of septic
acute kidney injury (AKI) in
adult Surgical
critically ill patient .
Methods One hundred
patients were divided into two groups ,the group of 63 cases of AKI and AKI group of 37 cases ,
plasma NGAL and
Cystatin C level of the 2 groups were determined by the
method of
enzyme‐linked
immunosorbent (
ELISA) ,
latex en‐hanced immune
turbidimetry (PETIA) respectively on arrival in the
surgical intensive care unit(SICU) (T0 ) and 24 h after arrival in SICU(T1 ) .Results Compared with
patients in non AKI group ,both
plasma NGAL and
Cystatin C level of
patients in AKI group on T0 and T1 increased significantly ,the difference between the two groups had significant statistical difference (P<0 .01);Although ,
plasma NGAL on T1 performed less well (
AUC=0 .69) ,with a threshold value of 92 ng/mL(70 .3%
sensitivity ,57%
specificity) .
Plasma NGAL showed significant discrimination for AKI
diagnosis (
AUC=0 .85) with a threshold value of 65 .95 ng/mL(81 .8%
sensitivity ,76 .2%
specificity) on T0 .Both
plasma Cystatin C on T0 and T1 worked well for the
diagnosis of AKI (
AUC=0 .90 ,0 .88 ,thresholds 1 .49 and 1 .47 mg/L ,respectively) ,with diagnostic
sensitivity of 89 .2% ,82 .5% respectively ,speci‐ficity of 83 .8% ,76 .2% respectively .Conclusion
Plasma NGAL and
Cystatin C are useful markers in predicting AKI in surgical
critically ill patients ,the
early diagnosis value of
plasma Cystatin C for AKI is better than
plasma NGAL on arrival in the
surgical intensive care unit .