Objective To
research correlation of
serum protein spectrometry and
lymphoma markers for
diffuse large B cell lymphoma (DLBCL)
patients. Whether there is relative between the
protein and
prognosis will be further researched.
Methods Serum protein spectrometry of 62 DLBCL
patients was detected by the
SELDI-TOF-MS technique and Weak
cation exchange 2 (WCX2) chip.
Lactate dehydrogenase (LDH) was detected by
biochemistry method. Beta-2-microglobulin (β2-MG) and
cancer antigen125(CA125)were detected by
enzyme-linked immunosorbent assay (
ELISA). The level of LDH, β2-MG and CA125 for DLBCL
patients between 11×103~12×103
protein expressed positively and negatively was analyzed. Meanwhile,correlation
analysis and
survival analysis were done. Results LDH, β2-MG and CA125 in 11×103~12×103protein expressed positive group were (523.30±435.96)U/L, (3.23±1.24)mg/L, (81.07±61.39)U/L respectively,and they were higher than that in negative group (P<0.05). 11×103~12×103
protein was positive correlated to LDH, β2-MG and CA125 (P<0.01). The
survival time in 11×103~12×103
protein expressed in positive group,in which median
survival time was 11 months, was shorter than that in negative group(P <0.01). The
survival time in LDH normal group was longer than that in increased group(P <0.01). The
survival time of β2-MG and CA125 had no significant difference between increased group and normal group. Conclusion LDH and 11×103~12×103
protein are expected to be
prognosis indicators for DLBCL
patients.