Objective To explore the effect of serpine1, α-
serpine1 protein and KLF2 in
patients with
lower extremity venous thrombosis by Fufang Xueshuantong
capsule.
Methods 44
patients were diagnosed with
lower extremity venous thrombosis were collected, and randomly divided into experimental group and
control group, 22 cases in each group, giving the conventional antiplatelet
therapy, on the basis of this, the experimental group was given Fufang Xueshuantong
capsule 1.5 g, three times a day orally, and the
control group was given context Shutong granules 20 g, three times a day orally.2 weeks for a
course of
treatment, three
courses of
treatment.Before and
after treatment in the
detection of two groups of
patients with
serum serpine1, α-serpine1 KLF2 and
protein contents,
blood rheology, coagulation function, and carries on the
analysis.ResuIts Compared with the
control group, experimental group
patients has better curative effect, the performance of
serum serpine1and α-
serpine1 protein content were significantly decreased(P<0.05).KLF2 expression was significantly higher (P<0.05).
Blood viscosity,
erythrocyte aggregation index, erythrocyte sedimentation rate decreased significantly (P<0.05).Fib, D-D content significantly decreased (P<0.05).ConcIusions Fufang Xueshuantong
capsule can reduce
serum serpine1, α-
serpine1 protein content and promote KLF2 expression, decrease the
blood viscosity,
erythrocyte sedimentation rate, improve
patients with hypercoagulable
state in
patients with
lower extremity venous thrombosis, so as to achieve good
clinical efficacy.