BACKGROUND:
Some control studies attempt to answer the advantages and disadvantages of high-
dose methylprednisolone sodium succinate therapy for acute
spinal cord injury in
adults, but have arrived at different conclusions.
OBJECTIVE:
To explore the
therapeutic efficacy of high-
dose methylprednisolone sodium succinate therapy on acute
spinal cord injury in
adults by Meta
analysis.
METHODS:
PubMed, Embase, Cochranel
Library, CBMdisc, VIP and WanFang Databases were searched by
computer, and relevant
Chinese and English orthopedic journals were retrieved by
hand. Controled trials related to high-
dose methylprednisolone sodium succinate therapy of acute
spinal cord injury in
adults were included. The
methodology quality of included trials was criticaly assessed. RevMan 5.0
software was used for
data analysis. RESULTS AND
CONCLUSION:
Nine clinical controled trials were included.
Meta-analysis results showed that compared with the conventional
therapy, the neurological recovery rate after 24 hours of
administration,
pneumonia incidence and gastrointestinal reactions increased significantly after high-
dose methylprednisolone sodium succinate therapy. However, there were no statistical differences in the rate of
urinary tract infection, nonunion rate and stress
ulcer incidence between these two
therapies. These findings indicate that the high-
dose methylprednisolone sodium succinate therapy on acute
spinal cord injury in
adults has better outcomes in neurological
function recovery, but can
lead to higher
incidence of
lung infection and gastrointestinal reactions. Therefore,
lung infection and gastrointestinal reactions should be avoided as much as possible during the
course of
treatment.