Roles of protein tyrosine phosphatase SHP2 in lung cancer / 中国药理学与毒理学杂志
Lingjuan HE; Hongqiang CHENG; Yuehai KE; Linrun WANG.
Chinese Journal of Pharmacology and Toxicology
; (6): 82-86, 2016.
Artículo
en Zh
| WPRIM | ID: wpr-488069
The reversible phosphorylation plays an important regulatory role in various pathological and physiological processes. Src Homology 2 domain containing protein tyrosine phosphatase (SHP2),a featured member of the protein tyrosine phosphatase family,is identified as the first PTP proto-oncogene. SHP2 is associated with breast cancer,leukemia,lung cancer,liver cancer,gastric cancer,laryngeal cancer,oral cancer and other types of cancer. Signalling pathways involving SHP2 have also been discovered. It has been recently reported that the high expression of SHP2 in lung cancer regulates cancer cell proliferation,metastasis and drug resistance. SHP2 may be a potential thera?peutic target because it is implicated in many diseases. This article focuses on the research progress in functions of SHP2 in lung cancer.
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