Objective To observe the effects of
dexmedetomidine on some
hemodynamics indexes and the total
dosage of
propofol and
remifentanil of laparoscopic total
hysterectomy.
Methods Sixty cases
patients with total
intravenous anesthesia in laparoscopic total
hysterectomy were randomly divided into two groups,30 cases in each group.After induction of
anesthesia,in the
dexmedetomidine group,10 min before
anesthesia induction pumping load
dexmedetomidine 0.5 μg/kg,and then continue pumped into the
maintenance dose of 0.2 μg/(kg · h),stop the
medicine in 40 min before the end of operation.The
control group were given the same capacity
normal saline.The
heart rate (HR),systolic
blood pressure (SBP),
mean arterial pressure (MAP),the total
dosage of
propofol and
remifentanil at different
time of before
anesthesia(T0),tracheal
intubation (T1),beginning of the operation (T2),extubation (T3) were recorded.Results Compared with the
control group,hemodynnmic stability(HR,SBP,MAP) of each
time of the
dexmedetomidine group were better than the
control group's,there were statistically significant differences (P<0.05).The total
dosage of
propofol,
remifentanil of the
dexmedetomidine group were (0.11.3 ± 0.013) mg/(kg · min),(0.098 ± 0.009) μg/(kg · min),of the
control group were (0.151±0.012) mg/(kg · min),(0.131±0.011) μg/(kg · min),the total
dosage of
dexmedetomidine group was less than the
control group's,there were significant differences(P=0.038,0.045).Conclusion Small
dose of
dexmedetomidine used in laparoscopic total
hysterectomy patients can reduce the total
dosage of
propofol and
remifentanil,more stable
hemodynamics at each point,and can be used as a viable programme for clinical application.