Objective: To investigate the influence of
edaravone on the expression of
growth arrest and
DNA damage -inducible
protein 34 (GADD34).
Methods: A total of 108 healthy
male Sprague-Dawley rats were randomly divided into sham operation group, model group and
edaravone group (36 cases for each group).
Transient focal
cerebral ischemia was induced by
middle cerebral artery occlusion for 2 h followed by
reperfusion in
Sprague-Dawley rats . Then, GADD34 expression was measured with
immunohistochemistry at different
time -points after
reperfusion in the peri-
infarct regions of all
rats .
Results: The GADD34 expression was detected in the peri-
infarct regions of
rats 1 h after
reperfusion , which reached its peak 24 h after
reperfusion . And
edaravone could significantly down-regulate the GADD34 expression.
Conclusions: Edaravon could down-regulate GADD34 expression, which suggests that
edaravone may exert an important function in inhibiting
endoplasmic reticulum stress reaction by scavenging
free radicals in the upper
stream .