Hepatitis B virus (HBV)-related
liver failure has an extremely high mortality rate and a complex pathogenesis,and since related mechanisms are not fully understood,it has been very difficult to
diagnose and treat this
disease in clinical practice.Apart from
liver transplantation,there is still a lack of specific and effective
drugs and
therapies for the medical
treatment of HBV-related
liver failure.This article summarizes our experience and
research achievements in the
diagnosis and
treatment of HBV-related
liver failure,explores the
association between host's
genetic background and development and
aggravation of
chronic hepatitis B,and elaborates on the phenomenon of three attacks and the concept of four
time phases.In the aspect of
treatment,this article focuses on the clinical application of
antiviral therapy,anti-infective
therapy,
glucocorticoids,and
stem cell transplantation;for the evaluation of
patients' condition,this article establishes a suitable system for evaluating the
prognosis of HBV-related
liver failure.