Drug control is still one of the main measures to control influenza. The current influenza prevention and treatmentdrugs mainly include M2 ion channel blockers and neuraminidase inhibitors. They have a certain therapeutic effect,but their resis?tance has also become increasingly prominent. In recent years,with the in-depth application of crystal lography,virology and other re?lated disciplines in the field of pharmacy,many new drugs have entered the(pre-)clinical test stage,and achieved good antiviral ef?fects. The most representatives include broad-spectrum anti-influenza virushemagglutinin antibody and viral RNA polymerase complex small molecule inhibitors. Here,we introduce some new drugs against influenza so as to provide a reference for the prevention and con?trol of influenzaepidemic.