This study aimed at exploring the inhibitory effect behind its mechanism on
acid-soluble
polysaccharides from G.incamatum in transplanted H22
tumor mice.Different indices,including
tumor inhibitory rate,organ index of
liver,
thymus and
spleen,
IL-2,IFN-γ and TNF-α were detected for the evaluation of anti-
tumor effects and the mechanism.Furthermore,HE
staining and
TUNEL assay were adopted to investigate the pathological changes of
tumor tissue and
cell apoptosis,respectively.As a result,the three
dose groups of acidsoluble
polysaccharides of G.incamatum successfully inhibited the proliferation of
tumor cells,while organ indexes of
spleen and
thymus were improved and
serum IL-2,IFN-γ and TNF-α increased.H&E
staining and
TUNEL assay showed the
polysaccharides induced
cell apoptosis,playing a significant
role in the inhibition of
tumor growth.In conclusion,
acid-soluble
polysaccharides of G.incamatum possessed significant anti-
tumor effects,behind which the mechanism could be related to the
regulation of immune
regulation,
cell apoptosis,and the
protection of
liver function.