Expression of transforming growth factor-?_1 in the chronic pancreatitis tissue: Pathogenesis of chronic pancreatitis / 中国普通外科杂志
Qilong CHEN; Guowei LI; Xiao CHEN; Renyong LIN; Xinjian XU; Hao WEN.
Chinese Journal of General Surgery
; (12)2001.
Artículo
en Zh
| WPRIM | ID: wpr-519865
Objective To study the effect and significance of transforming growth factor-?_1(TGF-?_1), and TGF-?_1mRNA in the pathogenesis of chronic pancreatitis. Methods The expression and distribution of TGF-?_1, and TGF-?_1mRNA in the pancreatic tissue in different stage of the pathogenesis of chronic pancreatitis were studied with immunohistochemical SP staining, in situ hybridization,and reverse transcription-polymerase chain reaction on the canine model of chronic pancreatitis . Results The Expression of TGF-?_1 and TGF-?_1mRNA were found in fibrotic tissues, fibroblasts, macrophages and endothelial cells of blood vessels.The expression of TGF-?_1 and TGF-?_1mRNA were high and lasting in the pathogenesis of chronic pancreatitis. Conclusions High expression of TGF-?_1 is closely related to the fibroblast proliferating activity, extracellular matrix overdeposition and proceeding fibrosis of pancreas.
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