Dynamic change of cytokines in splenocyte culture supernatants of mice after radiofrequency therapy / 中国病理生理杂志
Junping ZHANG; Hongming PAN; Houjun CAO; Lipeng HUANG; Jinmin WU.
Chinese Journal of Pathophysiology
; (12)1989.
Artículo
en Zh
| WPRIM | ID: wpr-528121
AIM:
To evaluate the influence of radiofrequency (RF) hyperthermia on immunity function in mice.METHODS:
The expression pattern of T helper type 1 (Th1) and T helper type 2 (Th2) cytokines in splenocyte culture supernatants, mainly the expression levels of IFN-?, IL-2, IL-4 and IL-10 in splenocyte culture supernatants of mice in tumor-bearing group, surgical resection group, RF therapy group and normal control group were detected by enzyme-linked immunoadsordent assay (ELISA).RESULTS:
IL-2 concentration in two weeks after RF therapy group was higher than that in two weeks after surgical resection and normal control groups (P0.05).CONCLUSION:
RF hyperthermia may activate the transformation from Th2 to Th1 and facilitate the excretion of Th1 type cytokines that play an important role in the anti-tumor immunity.
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