The
hypereosinophilic syndrome (HES) is a leukoproliferative disorder, marked by a sustained overproduction of
eosinophils and a predilection to damage specific organs. There are several diagnostic criteria. First, the
patient must sustained
blood eosinophilia of greater than 1,500/mm3, for longer than 6 months. Secondly, other apparent etiologies for
eosinophilia must be absent, ineluding
parasitic infections and allergic
diseases. Thirdly, the
patient must have
signs and symptoms of organ involvement. Cardiac and neurologic
diseases, frequent in HES, are major causes of
morbidity and
mortality. The damage to the
heart and
nervous system is due to
thrombosis and
fibrosis.
Gastrointestinal tract involvement can accompany HES, but severe eosinophilic
colitis was very rarely described in
association with this
syndrome. In this
report, we present a
patient with HES and eosinophilic
colitis who was successfully treated with
steroids.