Changes of Transepidermal Water Loss (TEWL) in Psoriatic Plaques during D-PUVA Therapy
Dae-Hun SUH; Tae-Eun KWON; Sang-Duck KIM; Seok-Bum PARK; Oh-Sang KWON; Kyu-Han KIM; Kyoung-Chan PARK.
Annals of Dermatology
; : 7-11, 2001.
Artículo
en Inglés
| WPRIM | ID: wpr-53030
BACKGROUND:
Psoriatic lesions have reduced water-holding capacity and show increased transepidermal water loss (TEWL). The effect of D-PUVA therapy, which combines topical calcipotriol and PUVA therapy, on epidermal barrier function has not yet been evaluated.OBJECTIVE:
The purpose of this study was to verify the change of TEWL in lesional and normal skin according to D-PUVA therapy in psoriasis patients.METHODS:
TEWL was measured consecutively by TEWAMETER TM210®, in 13 psoriasis patients who received D-PUVA therapy. Clinical grading was done according to psoriasis severity index (PSI).RESULTS:
TEWL of psoriatic lesion decreased as D-PUVA continued. TEWL of normal-looking skin gradually increased, although the increase was trivial. Clinical grading of scale and in-filtration followed the pattern of PSI in the decrease of TEWL, while that of erythema did not.CONCLUSION:
In psoriatic plaques, TEWL was decreased according to the improvement. In normal-looking skin, D-PUVA therapy caused only a little effect on TEWL.
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